HIPEC and PIPAC: Innovative Therapies for Advanced Cancer

Posted on Sept. 21, 2025, 8:36 p.m. by Dr Ramkishan Nag
hipec-and-pipac-innovative-therapies-for-advanced-cancer

HIPEC and PIPAC: Innovative Therapies for Advanced Cancer

Cancer treatment is constantly evolving, with new techniques emerging to combat even the most challenging cases. Two such innovative therapies gaining prominence are Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). Both aim to directly target cancer cells within the abdominal cavity, offering hope to patients with advanced or recurrent cancers.

HIPEC involves circulating heated chemotherapy drugs directly into the abdomen after surgical removal of visible tumors. The heat enhances the chemotherapy's effectiveness, while the direct delivery allows for higher concentrations of the drug to reach cancer cells, minimizing systemic side effects. This approach is particularly effective for cancers that have spread within the peritoneum, the lining of the abdominal cavity, such as certain types of colorectal, ovarian, and gastric cancers.

PIPAC, on the other hand, utilizes a minimally invasive approach. Chemotherapy drugs are aerosolized under pressure and delivered into the abdominal cavity via laparoscopy. The pressurized aerosol distribution ensures even drug penetration throughout the peritoneum, even in areas with difficult access. PIPAC is often used for patients with peritoneal carcinomatosis where complete surgical removal of tumors is not feasible, providing a means to control the disease and improve quality of life.

Dr. Ramkishan Nag, a highly skilled Surgical Oncologist based in Mumbai, is dedicated to bringing these advanced treatments to patients in India. With over a decade of experience and training at Tata Memorial Hospital, Mumbai, Dr. Nag possesses the expertise to determine if HIPEC or PIPAC is the right course of treatment for your specific situation. His practice, located at 1st Floor, Urban Grandeur, Kanakia, Mira Road 401105, Mumbai, Maharashtra, is committed to providing accessible and affordable world-class oncology care.

If you or a loved one is facing a diagnosis of advanced cancer, exploring innovative therapies like HIPEC and PIPAC could be a crucial step. Contact Dr. Ramkishan Nag to learn more about these options and receive a personalized treatment plan that combines medical excellence with genuine compassion. He specializes in gastrointestinal, colorectal, liver, pancreatic, gynecologic, and breast cancers and brings global standards of cancer care to India.

About Dr Ramkishan Nag
I am a highly skilled Surgical Oncologist with more than a decade of experience and over 5,000 cancer surgeries to my credit. I specialize in advanced laparoscopic and robotic techniques, offering patients faster recovery, minimal scarring, and organ-preserving options. My expertise spans gastrointestinal, colorectal, liver, pancreatic, gynecologic, and breast cancers.

Trained at the renowned Tata Memorial Hospital, Mumbai, and in cutting-edge procedures such as HIPEC and PIPAC, I bring global standards of cancer care to India. I am committed to ethical, evidence-based treatment and strive to make world-class oncology care accessible and affordable for every patient, combining medical excellence with genuine compassion.
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