HIPEC and PIPAC: Innovative Therapies for Advanced Abdominal Cancers

## HIPEC and PIPAC: Innovative Therapies for Advanced Abdominal Cancers

For patients facing advanced abdominal cancers that have spread within the peritoneal cavity, innovative therapies like HIPEC (Hyperthermic Intraperitoneal Chemotherapy) and PIPAC (Pressurized Intraperitoneal Aerosol Chemotherapy) offer hope and improved outcomes. These advanced techniques, while complex, can provide significant benefits in carefully selected cases, extending lifespan and enhancing quality of life when traditional treatments might be less effective. Understanding these options is crucial for patients seeking the most comprehensive and cutting-edge cancer care.

HIPEC, or Hyperthermic Intraperitoneal Chemotherapy, is a two-step procedure typically performed after cytoreductive surgery. During this surgery, as much visible tumor as possible is removed from the abdominal cavity. Following this, a heated chemotherapy solution is circulated throughout the abdomen for a specific period. The heat helps to enhance the penetration of the chemotherapy drugs, targeting any remaining cancer cells and improving treatment efficacy. This approach is particularly effective for cancers like peritoneal mesothelioma, appendiceal cancer, and certain types of colorectal and ovarian cancers.

PIPAC, or Pressurized Intraperitoneal Aerosol Chemotherapy, represents another promising approach. Unlike HIPEC, PIPAC involves the administration of chemotherapy drugs in aerosolized form under pressure within the abdomen. This method allows for a more even distribution of the chemotherapy agent throughout the peritoneal cavity, reaching areas that might be difficult to access with traditional methods. PIPAC is often considered for patients with advanced cancers where complete surgical removal of tumors may not be feasible.

Both HIPEC and PIPAC require a multidisciplinary approach involving skilled surgical oncologists, medical oncologists, and specialized support staff. Determining the suitability of a patient for either of these procedures involves careful evaluation of their overall health, the type and extent of their cancer, and other factors. Access to experienced professionals who are trained in these techniques is also essential for optimal outcomes.

Dr. Ramkishan Nag, a highly skilled Surgical Oncologist based in Mumbai, specializes in advanced laparoscopic and robotic techniques, including HIPEC and PIPAC. With over a decade of experience and training at Tata Memorial Hospital, Mumbai, Dr. Nag is committed to bringing global standards of cancer care to India, offering patients faster recovery, minimal scarring, and organ-preserving options. Located at Urban Grandeur, Kanakia, Mira Road, Dr. Nag strives to make world-class oncology care accessible and affordable, combining medical excellence with genuine compassion for every patient.